CRESCINA TRANSDERMIC FOLLICULAR ISLANDS HB 177

THE SINGLE FOLLICLE AND THE FOLLICULAR ISLANDS
The hair at first glance has two distinct structures: the first is the hair follicle, which resides in the skin, and the second is the stem, visible above the surface of the scalp. The hair follicle is a tunnel-shaped segment of the epidermis that extends in the lower part to the dermis. The structure contains several layers each of which has separate functions. At the base of the follicle is the papilla, which contains the capillaries, or tiny blood vessels that nourish the cells. The vital part of the hair is that which surrounds the papilla at the deepest level and is called the “bulb”.
But individual follicles aren’t the only structures on the scalp. At a magnification from 50x to 400x it can be observed that sometimes the hair stems emerge from the scalp in small clusters that come out of a single follicular ostium, each of which represents the visible, superficial portion of a more complex, but well defined, called the Follicular Island. The components of the follicular island are diverse and articulated: it can have from 2 to 4 terminal follicles, each of which contains the bulb that produces the terminal hair; from 1 to 2 fleece follicles each of which contains the bulb in the process of atrophying; there may also be a secondary hair germ composed of the cells of the dermal papilla which, upon contact with the stem cells of the bulge, will give rise to a new hair in anagen. The pilo-erector muscle also has a specific conformation in the follicular island: it is made up of bundles of muscles that branch off from a central body located just above the bulge area and that contact each single follicle. The follicular island has a rich network of blood vessels that reach every single follicle and a network of nerve fibers that innervate the follicles and muscle bundles. The follicular island is surrounded by a sort of membrane made up of collagen fibers that collects and protects it, called a “perifolliculus”.

THE IMPORTANCE OF FOLLICULAR ISLANDS
Bringing on average from 2 to more terminal hairs and various other quiescent or semi-atrophied follicles, the follicular island takes on strategic importance within the individual capillary heritage. In fact, unlike single follicles that are valid for only one hair, the follicular islands, depending on the
distribution and number, they can count two or more terminal hairs (on average 2.5). With the thinning process, the number not only of follicles but also of follicular islets decreases and it is therefore essential to reserve a specific treatment for the follicular islands that is appropriate to the complexity of this extremely important system, in proportion to the total number of stems on the scalp.

CRESCINA TRANSDERMIC ISOLE FOLLICOLARI HB 177
The new Crescina Transdermic Follicular Islands HB 177 is a formula characterized by the main active base – the Re-Growth complex (Cysteine, Lysine, Glycoprotein), the HFSC complex (Stem-Engine), the Follicular Islands Complex, 5 Enhancer – called Rapid -Intensive Follicular Islands Formula, which is associated with the new HAIR BOOSTER 177 (Curcuma Longa Callus Conditioned Media), to enhance the activity of the hair bulb (both in single follicles and in follicular islands) and promote the growth of new hair, with the insertion of the ATP molecule, together with Ribose, to supply vital energy to the cells of the hair bulb.
The particularly elaborate formula also contains the two PLC12 and Bulge-Stem treatments, with the technological innovation of the new Scalp Microbiome Complex. The PLC12 treatment (Swiss Patent CH 713 030) contains the complex of 12 Plate-Like molecules which, being synthetic substances similar to the endogenous peptide molecules naturally present in the hair system, are responsible for physiologically and synergistically promoting hair growth.
The Bulge-Stem treatment represents the formulation evolution of the HFSC complex (Swiss Patent CH 703 390) composed of Hydrolyzed Rice Protein and Eryobotrya Japonica, which is enriched with Dihydroquercetin-Glucoside and Tripeptide-10 Citrulline: it is able to protect and maintain intact
the environment of the bulge, inside the hair follicle, where the cells responsible for initiating new hair life cycles are stored.

TECNOLOGIA TRANSDERMIC CON 5 ENHANCER
Crescina Transdermic Follicular Islands HB 177 is a topical cosmetic treatment for physiological hair growth with Transdermal Technology, thanks to which the active substances of the Re-Growth complexes, HFSC, Plate-Like Complex and HB 177 can penetrate the system hair (single follicles and follicular islets) not only via the transfollicular pathway (opening of the follicle) but also transdermally through the skin layers of the scalp (ex vivo test with Franz cells) assisted by both their low molecular weight and presence of penetration facilitators, namely 5 Enhancers: Pentylene Glycol, Decylene Glycol, Caprylyl Glycol, Propylene Glycol and Butylene Glycol which improve the absorption of functional molecules in the scalp (Swiss Patent 711 466).

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